SIRT1 and aging related signaling pathways - PubMed
In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will be …
Regulation of SIRT1 in aging: Roles in mitochondrial function and ...
Silent information regulator-1, also known as sirtuin 1 (SIRT1), has been reported to be involved in the regulation of various important biological processes, including inflammation, …
Sirtuins and their Biological Relevance in Aging and Age-Related ...
Here, we summarize some of the recent discoveries in sirtuin biology that clearly implicate the functions of sirtuins in the regulation of aging and age-related diseases.
Sirtuins, a promising target in slowing down the ageing process
One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, …
SIRT1 and aging related signaling pathways - ScienceDirect
Apr 1, 2020 · In this review, the relationship between SIRT1 and aging and various signaling networks associated with aging, including NF-κB, AMPK, mTOR, P53, PGC1α, and FoxOs will …
SIRT1 and SIRT6: The role in aging-related diseases
Oct 1, 2023 · Of the seven mammalian SIRT isotypes (SIRT1–7), SIRT1 and SIRT6 are well-recognized for regulating signaling pathways related to aging. Herein, we review the protective …
Sirtuins, Cell Senescence, and Vascular Aging - PubMed
The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …
SIRT1 is downregulated by autophagy in senescence and ageing
Sep 28, 2020 · Our study reveals a mechanism in the regulation of the protein homeostasis of SIRT1 and suggests a potential strategy to stabilize SIRT1 to promote productive ageing. …
SIRT6 Widely Regulates Aging, Immunity, and Cancer - PMC
SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), …
Restoration of energy homeostasis by SIRT6 extends healthy ... - Nature
May 28, 2021 · These findings show that SIRT6 optimizes energy homeostasis in old age to delay frailty and preserve healthy aging. Aging is associated with increased frailty and disrupted …
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