HaCaT is a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin, [1] [2] widely used in scientific research. [3] HaCaT cells are utilized for their high capacity to differentiate and proliferate in vitro. [4]

HaCaT cells are the immortalized human keratinocytes and have been extensively used to study the epidermal homeostasis and its pathophysiology. T helper cells play a role in various chronic dermatological conditions and they can affect skin barrier homeostasis.

HaCaT cells are a long-lived, spontaneously immortalized human KC line, which exhibit basal cell properties and display substantial changes in response to two well-established in vitro prodifferentiating agents: the increase in cell density, as a function of time in culture, and extracellular Ca 2+ concentration.

Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature. Short tandem repeat profiling provides an international reference standard for human cell lines.

Spontaneously immortalized human keratinocytes, HaCaT are a model to study the epidermal homeostasis and pathophysiology. In contrast to what has been previously described, here, we show that HaCaT can be efficiently ciliated.

HaCaT cells are a spontaneously immortalized, human keratinocyte line that has been widely used for studies of skin biology and differentiation. Under typical culture conditions HaCaT cells have a partially to fully differentiated phenotype due …

HaCaT cells are a spontaneously immortalized human keratinocyte cell line originating from adult skin and representing a unique evolutionary pathway. These cells possess mutations in both alleles of the p53 gene, which is typical for mutations induced by UV radiation [3,4].

Jan 5, 2022 · A spontaneously transformed human epithelial cell line developed from a long-term primary culture of human adult skin KERATINOCYTES. As it maintains an epidermal differentiation capacity, it has been used as a model for keratinization studies. (From:J Cell Biol. 1988 Mar;106 (3):761-71.)

HaCaT cells are a human epidermal keratinocyte line that has been used for investigation of multistep carcinogenesis in human cells (Boukamp et al. 1988). HaCaTs retain epidermal keratins characteristic of the more differentiated cell layers of human epidermis in vivo and are useful for in vivo analysis ( Breitkreutz et al. 1991 ).

Dec 17, 2017 · HaCaT cells are a long-lived, spontaneously immortalized human KC line, which exhibit basal cell properties and display substantial changes in response to two well-established in vitro prodifferentiating agents: the increase in cell density, as a function of time in culture, and extracellular Ca 2+ concentration.