Figure 1: Performance of CONCOCT and other unsupervised binning methods on a synthetic community. We based the simulations of the mock data sets on 16S rRNA samples from the Human Microbiome ...

Unsupervised binning methods do not require data from reference genomes. We develop a method that uses single-molecule, real-time (SMRT) sequencing of metagenomic DNA to capture methylated motifs.