Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.

Feb 4, 2024 · RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell …

Feb 20, 2020 · Aspartimide formation leads to low yields in addition to costly purification or even inaccessible peptide sequences. Here, we report an alternative approach to address this …

Formation of isoaspartic acid (isoAsp) is a common modification of aspartic acid (Asp) or asparagine (Asn) residue in proteins. Differentiation of isoAsp and Asp residues is a …

1 day ago · KEY TAKEAWAYS. RGD peptides are short, integrin-binding sequences (Arg-Gly-Asp) enabling targeted drug delivery and cellular internalization.; They are pivotal in cancer …

Using model peptides, a mechanism of formation of the Lys-Asp crosslink was elucidated. The mechanism involves spontaneous peptide cleavage on the C-terminal side of Asp residues …

1 day ago · Peptides with glycine or serine adjacent to Asp or Asn are more prone to cyclization due to reduced steric hindrance. Elevated temperatures and prolonged exposure to mildly …

2 days ago · Functionalizing peptide sequences with cell adhesion motifs enhances their cellular bioactivity. Numerous studies have focused on incorporating the Arg-Gly-Asp (RGD) motif into …

Aspartic acid (aspartate, Asp) is a biologically non-essential amino acid identified by the hydrolysis of asparagine. Aspartate comprises two isoforms: the predominant form is L …

Jul 15, 2019 · We observed Fmoc-SPPS chain termination at the N-terminal Xaa-Asp-Yaa motif apparently caused by formation of cyclo(-Xaa-Asp)-Yaa peptides. These peptides were …