Vitamin B 12 is derived from a tetrapyrrolic structural framework created by the enzymes deaminase and cosynthetase which transform aminolevulinic acid via porphobilinogen and hydroxymethylbilane to uroporphyrinogen III. The latter is the first macrocyclic intermediate common to heme, chlorophyll, siroheme and B 12 itself.

Cobalamin is an essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism.

Jul 14, 2022 · The examination of the vitamin’s molecular structure helps scientists to have a better understanding of how the body utilizes Vitamin B 12 into building red blood cells and preventing pernicious anemia syndromes.

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production.

The center-piece in the structure is of course the cobalt(III), the octahedral coordination to five nitrogens and a carbon is common to all three cobalamins, and can be found in a number of simple coordination complexes.

The chemistry and biochemistry of the vitamin B 12 compounds (cobalamins, XCbl) are described, with particular emphasis on their structural aspects and their relationships with properties and function.

Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria, and is necessary for DNA synthesis and cellular energy production.

Mar 27, 2024 · Figure 13.1 shows the structure of Vit B12 and the main structural features / challenges of the complex molecule.

Feb 26, 2025 · Vitamin B12 is an octahedral compound that contains cobalt ions. Its central structure is composed of a corrin ring connected to four pyrrole groups and a 5,6-dimethylbenzimidazole (DMBI) ligand. The cobalt ion is chelated to …

The structure of vitamin B12 has been examined by the X-ray analysis of four different crystal structures, air-dried and wet vitamin B12, the selenocyanate derivative of B 12, and a hexacarboxylic acid prepared by the degradation of the vitamin by Cannon, Johnson and Todd.