Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5′ position. Its main role is as substrate for the synthesis of RNA during transcription.

CTP (cytidine triphosphate) synthetase catalyzes the last committed step in pyrimidine nucleotide biosynthesis: [3] ATP + UTP + glutamine → ADP + P i + CTP + glutamate. It is the rate-limiting enzyme for the synthesis of cytosine nucleotides from both …

CTP——三磷酸胞苷，CTP由一个胞嘧啶，一个核糖，三个磷酸连接而成的。 每个分子去掉二个磷酸后是构成 RNA 的基本单位。 具体作用. ATP： CTP： DNA复制时的引物和转录时的鸟嘌呤核苷酸的提供者。 是三羧酸循环中琥珀酰辅酶A转变为琥珀酸过程中的能量载体，它可以和ATP相互转换。 UTP： 要用途是RNA合成（转录）时的原料，是RNA合成的直接前体。 GTP： 经UTP氨化由酶催化合成，一种在胞苷的核糖-5'－OH基上结合三分子磷酸的核苷酸；有二个高能磷酸键。 …

CTPS is a glutamine amidotransferase enzyme that catalyzes the conversion of uridine triphosphate (UTP) to CTP and is a key enzyme in nucleic acid and phospholipid biosynthesis (Fig. 2.2). Two human isoforms, CTPS1 and CTPS2, are 74% identical at the amino acid level (Kursula et al., 2006).

The CTP nucleotide is a key precursor of nucleic acids metabolism essential for DNA replication. De novo CTP production relies on CTP synthetases 1 and 2 (CTPS1 and CTPS2) that catalyze the conversion of UTP into CTP.

Cytidine triphosphate (CTP) synthase (no. 10) catalyzes the formation of CTP from UTP using the amide group of glutamine in an ATP-dependent reaction (Figure 3(a)). Only at the time of DNA replication, the deoxynucleotide pools increase noticeably.

Oct 10, 2005 · CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both substrates, the triphosphate moiety.

The transition of CTP synthase from an inactive dimer to an active tetramer is regulated by ATP, UTP, and CTP binding. We propose that the dimer can also partition into filaments in an inactive state.

Aug 1, 2004 · CTP synthetase (CTPs) catalyzes the last step in CTP biosynthesis, in which ammonia generated at the glutaminase domain reacts with the ATP-phosphorylated UTP at the synthetase domain to give CTP. Glutamine hydrolysis is active in the presence of ATP and UTP and is stimulated by the addition of GTP.

Filamentous polymers of CTPS appear to be universally conserved, having been observed in bacteria, yeast, flies, and human cells. 1-3,13 CTPS is a focal point for regulation of pyrimidine levels, as it directly converts UTP to CTP.