The ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes. Identification of the gene mutated in ob led to the discovery of the hormone leptin, which is important in the control of appetite.

000632 B6.Cg- Lep ob /J Mice homozygous for the obese spontaneous mutation, Lep ob (commonly referred to as ob or ob/ob ), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. They …

The obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).

Dec 1, 2006 · Here, we describe PDN in leptin-deficient (ob/ob) mice, a model of obesity and mild type 2 diabetes (17, 18) that is clearly characterized by manifest motor and sensory nerve conduction deficits, small sensory nerve fiber neuropathy, intraepidermal sensory nerve fiber loss, and oxidative-nitrosative stress in peripheral nerve, spinal cord, and d...

This study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...

Summary of obese mouse models of MetS. The Lep ob/ob, LepR db/db and A y /a mice are the three most commonly used spontaneously mutant obese mouse models. They display IR and can even develop diabetes depending on the background strain.

Leptin-deficient ob/ob mice were injected with mouse embryonic fibroblasts, which formed adipose tissue in vivo and prevented the metabolic abnormalities of leptin deficiency.

Also known as B6 ob, these animals are homozygous for the obese spontaneous mutation, Lep ob (often referred to as ob or ob/ob), show obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin. Ob/ob mice are also hypometabolic, hypothermic, and often subfertile.

Two specific mutations in inbred mouse strains: the “obese” (ob/ob) and “diabetic” (db/db) mouse mutations, were instrumental in legitimizing obesity research and the molecular basis for metabolic regulation.

Jun 28, 2021 · Ob/ob mice are characterized by a mutation of the obese (ob) gene encoding leptin, whereas the db/db mice have a mutation of the diabetes (db) gene encoding for the ObR [20].