Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua.

Mifepristone, and also known by its developmental code name RU-486, is a drug typically used in combination with misoprostol to bring about a medical abortion during pregnancy. [8] This combination is 97% effective [9] during the first 63 days (9 weeks) of pregnancy, yet effective in the second trimester as well.

ChemSpider record containing structure, synonyms, properties, vendors and database links for Mifepristone, 84371-65-3, Mifestone, VKHAHZOOUSRJNA-GCNJZUOMSA-N

Jan 5, 2015 · Chemical structure: This structure is also available as a 2d Mol file Other names: 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; Mifegyne; RU-38486; RU-486; Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)-, (11β,17β)-; 17β-hydroxy-11β-[4-(dimethylamino)-phenyl]-17α-(prop-1 ...

Feb 28, 2024 · Mifepristone, also called RU-486, is a synthetic steroid with dual FDA-approved applications. Firstly, it is utilized in combination with misoprostol for pregnancy termination up to 10 weeks of gestation, offering a medical alternative to surgical procedures for induced abortions.

Mifepristone, the synthetic steroid used to control transgene expression of the Gene-Switch vector, is an approved clinical drug.

Mifepristone-d3 | C29H35NO2 | CID 46782374 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

About its Science, Chemistry and Structure. Mifepristone is a synthetic steroid with anti-progestagenic and anti-glucocorticoid effects. It is useful in humans as an abortifacient in the first two months of pregnancy.

Objective: Mifepristone (RU486), a chemical abortifacient, has recently been used in clinical trials for psychotic depression and cancer chemotherapy.

Jan 2, 2024 · Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. The discovery of the first competitive progesterone antagonist, Mifepristone, has stimulated an intense search for more potent and more selective antiprogestins [1].