Apr 29, 2020 · In this review, we provide an overview of the composition of the JNK signaling pathway, its regulation of insulin signaling pathway, and the relationship between the JNK signaling pathway and other pathways in insulin resistance.

JNK affecting insulin resistance is a member of the MAPKs superfamily and plays the essential role at the core of inflammatory response and oxidative stress. In the different tissues of obese subjects, inflammatory factors can be observed to cause continuous activation of JNK.

JNK mediates many of the effects of stress on insulin resistance through inhibitory phosphorylation of insulin receptor substrate, and suppression of the JNK pathway has been shown to improve insulin resistance and glucose tolerance.

JNK was proposed to drive insulin resistance in obesity by four distinct mechanisms: direct inhibitory phosphorylation of insulin receptor substrates (IRS) 1 and 2; promotion of metabolic inflammation; promotion of metabolic efficiency and adiposity via inhibition of the TSH-thyroid hormone axis; and negative regulation of the PPARα-FGF21 axis .

Nov 21, 2002 · The c-Jun amino-terminal kinases (JNKs) can interfere with insulin action in cultured cells and are activated by inflammatory cytokines and free fatty acids, molecules that have been implicated in the development of type 2 diabetes. Here we show that JNK activity is abnormally elevated in obesity.

The notion that phosphorylation of IRS1 by activated JNK in obesity is a major mechanism of insulin resistance and impaired glucose metabolism is now widespread. Hence, this is one of many possible mechanisms by which JNK activation links insulin resistance during the course of …

Recent studies have identified the stress-responsive Jun-N-terminal kinase (JNK) pathway as a regulator of IIS signaling, providing a link between environmental challenges and metabolic regulation. JNK inhibits IIS activity and, thus, promotes lifespan extension and stress tolerance.

Sep 5, 2008 · It has been established that c-Jun N-terminal kinase 1 (JNK1) is essential to the pathogenesis of insulin resistance and type 2 diabetes. Although JNK influences inflammatory signaling pathways, it remains unclear whether its activity in macrophages contributes to adipose tissue inflammation and ultimately to the regulation of systemic metabolism.

Feb 1, 2017 · JNK was proposed to drive insulin resistance in obesity by four distinct mechanisms: direct inhibitory phosphorylation of insulin receptor substrates (IRS) 1 and 2; promotion of metabolic inflammation; promotion of metabolic efficiency and adiposity via inhibition of the TSH-thyroid hormone axis; and negative regulation of the PPARα-FGF21 axis ...

JNK mediates many of the effects of stress on insulin resistance through inhibitory phosphorylation of insulin receptor substrate, and suppression of the JNK pathway has been shown to improve insulin resistance and glucose tolerance.