The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion.

Jul 3, 2023 · Glucagon-like peptide-1 agonists. GLP-1 receptor agonists. Incretin mimetics. GLP-1 analogs. These medications are relatively new. The U.S. Food and Drug Administration (FDA) approved the first GLP-1 agonist (exenatide) in 2005. Researchers are still learning about their other potential uses and benefits.

Feb 29, 2024 · GLP-1 agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat T2DM and, in some cases, obesity. Examples of drugs in this class include Exenatide, Liraglutide, Dulaglutide, and Semaglutide.

Sep 18, 2024 · The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell...

Glucagon-like peptide-1 receptor agonists gained approval as drugs to treat diabetes and obesity starting in the 2000s. Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24.11 (NEP 24.11) and renal clearance , resulting in a half-life of approximately 2 minutes.

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are the hormones responsible for the incretin effect, and together they account for up to 60% of postprandial insulin release (Nauck et al., 1986).

Dec 2, 2024 · Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from the intestine that regulates glucose metabolism by stimulating insulin release, inhibiting glucagon secretion, and suppressing gastric motility.

Glucagon-like Peptide 1 receptor (GLP-1R) is one of the best characterized GPCRs involved in glucose homeostasis and is predominantly expressed in pancreatic β-cells, brain, heart, kidney and gastrointestinal tract [29].

Sep 18, 2024 · Additionally, this paper explores the potential applications of GLP-1 receptor agonists (GLP-1RAs) in fields such as neuroprotection, anti-infection measures, the reduction of various types of inflammation, and the enhancement of cardiovascular function.

Glucagon-like peptide-1 (GLP-1) receptor agonists, also known as GLP-1 analogs, GLP-1DAs, or incretin mimetics, [1] are a class of anorectic drugs that reduce blood sugar and energy intake by activating the GLP-1 receptor.They mimic the actions of the endogenous incretin hormone GLP-1, which is released by the gut after eating.. GLP-1 agonists were initially developed for type 2 …