Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1 , a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis .

Jan 26, 2023 · Aromatase inhibitors are drugs used to prevent cancer recurrence in women with estrogen-sensitive breast cancer. Learn about dosages and side effects.

Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial roles on a spectrum of developmental and physiological processes. The biological actions of estrogens are classically mediated by binding to two estrogen receptors (ERs), ERα and ERβ.

While men and cancer patients seek to lower aromatase -- an enzyme that helps the body produce estrogen -- women with menopausal symptoms or other hormone imbalances may benefit from increasing aromatase.

Jul 4, 2023 · Aromatase inhibitors decrease estrogen by inhibiting the conversion of testosterone to estrogen and have therefore been used in patients with short stature and/or constitutional delay of puberty. Lowering estrogen levels is associated with an increase in LH, FSH, and testosterone.

Learn more about aromatase inhibitors, including the three types, why they’re used in breast cancer treatment, their side effects, and their benefits.

Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced oestrogens in the differentiation, regulation and normal function of several organs and processes. This review is an overview of the role of aromatase in ...

Aromatase is an enzyme that converts androgens into estrogens, and aromatase inhibitors (AIs) can eliminate the production of estrogen. Furthermore, antiestrogens can bind to ER and antagonize its activity.

Aromatase catalyzes three separate steroid hydroxylations involved in the conversion of androstenedione to estrone. The first two give rise to 19-hydroxy and 19-aldehyde structures, and the third, although still controversial, probably also …

The aromatase cytochrome P450 (P450arom) enzyme, or estrogen synthase, which is coded by the CYP19A1 gene, is widely expressed in a subpopulation of excitatory and inhibitory neurons, astrocytes, and other cell types in the human brain. Experimental ...