Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder of the motor neurons, characterized by focal onset of muscle weakness and incessant disease progression.

Feb 12, 2024 · Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive, paralytic, neurodegenerative disease affecting the upper and lower motor neurons. ALS is the most common motor neuron disease (MND) and has both sporadic and familial forms.

Disease mechanisms (i.e. the process of ALS disease) help define causes of ALS. Researchers from all over the world are working to better understand ALS disease mechanisms. ALS is a heterogeneous disease, meaning that there are many diverse ways that disease can occur.

Amyotrophic lateral sclerosis (ALS), also know as Lou Gehrig's disease, is a fatal neurological disorder with an adult-onset around 54–67 years old, and it belongs to a group of conditions known as Motor Neurone Diseases (MND).

In this review, different aspects of ALS are discussed, including epidemiology, aetiology, pathogenesis, clinical features, differential diagnosis, investigations, treatment and future prospects. Keywords: amyotrophic lateral sclerosis, sporadic and familial ALS, TDP‐43 pathology.

Sep 15, 2024 · This review offers an in-depth examination of amyotrophic lateral sclerosis (ALS), addressing its epidemiology, pathophysiology, clinical presentation, diagnostic techniques, and current as well as emerging treatments.

Apr 10, 2024 · Amyotrophic lateral sclerosis (a-my-o-TROE-fik LAT-ur-ul skluh-ROE-sis), known as ALS, is a nervous system disease that affects nerve cells in the brain and spinal cord. ALS causes loss of muscle control.

May 9, 2012 · Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by death of pyramidal neurons in the motor cortex (upper motor neurons) and motor neurons in the brain stem and central spinal cord (lower motor neurons).

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder that causes selective death of motor neurons followed by paralysis and death. A subset of ALS cases is caused by mutations in the gene for Cu, Zn superoxide dismutase (SOD1), which impart a toxic gain of function to this antioxidant enzyme.

Jun 27, 2024 · ALS, or amyotrophic lateral sclerosis, is a neurodegenerative condition that affects the nerve cells (neurons) in your brain and spinal cord. It targets your motor neurons. These regulate voluntary muscle movements (like the ones you use to talk, chew and move your arms and legs) and breathing.