Here, we evaluated the effects and mechanisms of miR-155 in HBV-associated antigen-induced macrophage activation. First, co-culture assay of HepG2 or HepG2.2.15 cells and RAW264.7 macrophages showed that HepG2.2.15 cells could significantly promote macrophages to produce inflammatory cytokines.

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Jan 18, 2018 · Mechanistically, we unveiled that NF-κB and PI3K signal pathway mediated miR-155 expression induced by HBeAg stimulation in macrophages and the inductive miR-155 raised the production of inflammatory cytokines by targeting BCL …

Upregulation of monocyte miR-155 was observed in β-thalassemia/HbE patients. Increased miR-155 was associated with reductions in BTB and CNC Homology1 (BACH1) target gene expression and increased phagocytic activity of β-thalassemia/HbE monocytes.

Aug 15, 2019 · In the present study, we found that different concentrations of PM 2.5 caused a biphasic effect on proliferation of human bronchial epithelial (HBE) cells. PM 2.5 induced an aberrant cell cycle and proliferation of HBE cells, and up-regulated miR-155 levels with a concentration-dependent manner.

Feb 27, 2023 · Multifunctional microRNA-155 (miR-155) elevation in malaria, dengue virus (DENV), the thalassemias, and SARS-CoV-1/2, plays critical antiviral and cardiovascular roles through its targeted translational repression of over 140 genes.

Elevated miR-155 expression leads to fewer erythroid progenitors and erythrocytes during erythropoiesis (Georgantas 3rd et al., 2007; Li et al., 2023). miR-155 expression is significantly higher in myelodysplastic syndrome (MDS),

Aug 15, 2019 · In the present study, we found that different concentrations of PM 2.5 caused a biphasic effect on proliferation of human bronchial epithelial (HBE) cells. PM 2.5 induced an aberrant cell cycle and proliferation of HBE cells, and up-regulated miR-155 levels with a concentration-dependent manner.

Plasma miR-451 and miR-155 levels were significantly associated with the degree of β 0-thalassemia/HbE disease severity. The severe cases exhibited significantly higher levels of miR-451 and...

Aug 15, 2017 · In this study, we found that miR-155 was increased in As-HBE-T cells, and down-regulation of miR-155 by its inhibitor reduced the malignant phenotypes of arsenite transformed cells. Moreover, inhibition of miR-155 was revealed to …