Leqembi - ALZFORUM
Overview Name: Synonyms: Lecanemab-irmb, BAN2401, mAb158 Therapy Type: Immunotherapy (passive) (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: BioArctic AB, Biogen, Eisai Co., Ltd. Background BAN2401 is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble Aβ protofibrils ...
ALZFORUM | NETWORKING FOR A CURE
4 days ago · Could treating Alzheimer’s disease be as simple as inhaling xenon? Data from mice support this provocative idea. Huffing xenon for 40 minutes weekly shifted microglia from pro-inflammatory to phagocytic, allowing these immune cells to better corral plaques and prevent neurite degeneration. A Phase 1 trial in healthy elderly volunteers has started.
Fast Plaque Clearance with Little ARIA? So Teases ... - ALZFORUM
Part 1 of 9: Fast Plaque Clearance with Little ARIA? So Teases Trontinemab at AD/PD 2024 Part 2 of 9: TauRx Parses Subgroups to Make the Case for Methylene Blue Derivative, Again Part 3 of 9: Therapeutic Contenders Target Hard-to-Reach Pockets of Tau Part 4 of 9: Mouse Models and Markers for Cerebral Amyloid Angiopathy, ARIA Part 5 of 9: At ADPD, Scientists Dissect the Ins and Outs of Tau ...
Databases - ALZFORUM
AlzAntibodies This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease. AlzBiomarker This interactive database captures two decades of research on fluid biomarkers for Alzheimer's disease. Curated measurements and related data from peer-reviewed articles are presented, as well as meta-analyses for selected biomarkers. This ...
Aduhelm - ALZFORUM
Jan 3, 2016 · Overview Name: Synonyms: Aducanumab, BIIB037 Therapy Type: Immunotherapy (passive) (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: Biogen, Neurimmune Background BIIB037 is a high-affinity, fully human IgG1 monoclonal antibody against a conformational epitope found on Aβ. It was originally derived by the biotech company Neurimmune ...
ALZ-801 - ALZFORUM
Sep 23, 2024 · Background This is a prodrug of homotaurine, a modified amino acid previously developed under the names tramiprosate and Alzhemed™. ALZ-801 is converted to homotaurine in vivo, but is more easily absorbed and lasts longer in the blood than tramiprosate.
Trontinemab - ALZFORUM
Overview Name: Synonyms: RO7126209, RG6102 , Brain shuttle gantenerumab Therapy Type: Immunotherapy (passive) (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: Hoffmann-La Roche Background RO7126209 is a new version of the anti-amyloid monoclonal antibody gantenerumab, engineered to more easily cross the blood-brain barrier using ...
Rising Leqembi Prescriptions Are Straining Clinic Capacity
“It has changed the face of our practice,” Erik Musiek at Washington University in St. Louis told Alzforum. “There is a path forward after a diagnosis.” Rougher seas may lie ahead. Demand for the drug is accelerating and will soon outstrip the capacity of specialized dementia clinics to take on new patients. AD researchers agree that general neurology clinics will have to step up to ...
Donepezil - ALZFORUM
May 16, 2023 · Overview Name: Donepezil Synonyms: Aricept™, Donepezil hydrochloride, Eranz®, E 2020 Chemical Name: 2- [ (1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one Therapy Type: Small Molecule (timeline) Target Type: Cholinergic System (timeline) Condition (s): Alzheimer's Disease, Dementia with Lewy Bodies, Down's Syndrome, Parkinson's Disease Dementia U.S. FDA Status: Alzheimer ...
CT1812 - ALZFORUM
Nov 9, 2024 · Overview Name: Synonyms: Elayta Therapy Type: Small Molecule (timeline) Target Type: Amyloid-Related (timeline) Condition (s): Alzheimer's Disease U.S. FDA Status: Company: Cognition Therapeutics Inc. Background CT1812 is a small-molecule antagonist of the sigma2 receptor. The rationale behind this therapeutic approach is that ligands for the sigma2 receptor complex are negative allosteric ...