Interprotomer disulfide-stabilized variants of the human ...
Sep 22, 2021 · Here we investigate the impact of stabilizing disulfides, especially interprotomer disulfides (IP-DSs) linking protomers of the F trimer, on the elicitation of HMPV-neutralizing …
Structure-based design of a single-chain triple-disulfide ... - PLOS
Sep 22, 2023 · However, the triple disulfide-stabilized pre-F adsorbed HMPV-directed responses from commercially available pooled human immunoglobulin more fully than post-F. …
EMDB < EMD-23625 - EMBL-EBI
Sample: HMPV F v3-B in complex with MPE33 Deposition Authors: Gorman J , Kwong PD Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein …
Structure-based design of a single-chain triple-disulfide-stabilized ...
Sep 23, 2023 · However, the triple disulfide-stabilized pre-F adsorbed HMPV-directed responses from commercially available pooled human immunoglobulin more fully than post-F. …
Here we investigate the im-pact of stabilizing disulfides, especially interprotomer disulfides (IP-DSs) linking protomers of the F trimer, on the elicitation of HMPV-neutralizing responses.
Characterization of prefusion-F-specific antibodies ... - Cell Press
Human metapneumovirus (hMPV) infections can lead to severe outcomes for the elderly. Rush et al. use engineered hMPV fusion proteins to isolate and characterize antibodies generated from …
Profiling of hMPV F-specific antibodies isolated from human …
May 10, 2022 · Here we report 113 hMPV-F specific monoclonal antibodies (mAbs) isolated from memory B cells of human donors. We characterize the antibodies’ germline usage, epitopes, …
Profiling of hMPV F-specific antibodies isolated from human …
May 10, 2022 · In this study, we report a large panel of hMPV F-specific mAbs isolated from memory B cells of multiple healthy human donors. Some of the isolated mAbs exhibit ultra …
Antibody recognition of the Pneumovirus fusion protein trimer
Oct 9, 2020 · To further define the humoral immune response to the hMPV F protein, we isolated two new human monoclonal antibodies (mAbs), MPV458 and MPV465. Both mAbs are …
Potently neutralizing and protective anti-human metapneumovirus ...
Sep 13, 2022 · Mature hMPV F is a trimer of disulfide-linked heterodimers that adopts a metastable pre-fusion (preF) conformation, and neutralizing antibodies inhibit its transition to …