Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 5 NFL odds, lines and trends. Here’s what you need to know.

Head coach Kyle Shanahan indicated some schematic changes may be necessary, especially once defensive tackle Javon Hargrave ...

New England Patriots quarterback Jacoby Brissett, foreground, and teammates walk out of a tunnel before an NFL football game ...

When the San Francisco 49ers (2-2) and Arizona Cardinals (1-3) play on Oct. 6 at Levi's Stadium, Brock Purdy and Kyler Murray ...

Tight end George Kittle briefly exited with a rib injury, but he returned. Wide receivers Jacob Cowing (shoulder) and Chris ...

SANTA CLARA -- Brock Purdy threw a touchdown pass, Fred Warner returned an interception for a score and the San Francisco ...

The San Francisco 49ers (1-2) host the New England Patriots (1-2) at Levi's Stadium on Sunday, September 29, 2024. The 49ers ...

Brock Purdy threw a touchdown pass, Fred Warner returned an interception for a score and the San Francisco 49ers snapped a ...

Brock Purdy completed 15 of 27 passes for 288 yards and a touchdown Sunday to help the San Francisco 49ers end a two-game ...

Just about everything was going the way of the San Francisco 49ers on Sunday afternoon, so much so that quarterback Brock ...

The Patriots travel to Santa Clara to battle the 49ers at 4:05 p.m. on Boston 25. The Patriots are looking to snap a 2-game ...

The Patriots beat themselves quite a bit throughout Sunday's 30-13 defeat in San Francisco, gifting three turnovers to a ...