Background: Methotrexate (MTX) is an anti-folate drug with anti ... due to MTX treatment (3). Thymidylate synthase (TYMS) is involved in thymidine synthesis. MTX decreases TYMS activity by inhibition ...

manchester.ac.uk Background Patients with rheumatoid arthritis (RA) who take methotrexate (MTX) are advised to limit their alcohol intake due to potential combined hepatotoxicity. However, data are ...

5-Fu/LV prevents cell proliferation by inhibiting thymidylate synthase, which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. While 5-Fu has been shown to cause ...

1997). PMX and its polyglutamated derivatives inhibit thymidylate synthase (TYMS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide transformylase (GART), all of which are involved in ...