Background: Methotrexate (MTX) is an anti-folate drug with anti ... due to MTX treatment (3). Thymidylate synthase (TYMS) is involved in thymidine synthesis. MTX decreases TYMS activity by inhibition ...

Another antimetabolite, methotrexate, inhibits dihydrofolate reductase, thereby depleting cells of reduced folates, which are required for DNA synthesis. Alkylating agents. Theseinclude melphalan ...

In eukaryotes, PUFAs can be de novo synthesized through two independent biosynthetic pathways: the desaturase/elongase pathway and the PUFA synthase pathway. Among them, PUFAs synthesized through the ...

1 There were remarkable baseline differences: patients developing AAA had more long-standing, severe disease and less often used concomitant medication including lower doses of methotrexate (MTX), ...

Cotton, being the chief source of natural fiber, contributes 1.8% of the gross domestic production (GDP) in the form of foreign earnings from the sale of textile products across the globe. Pakistan ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...