The quest to resurrect the woolly mammoth on Earth has taken another, well, small step with the creation of the Colossal ...

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and ...

Mayo Clinic's Precision Mouse Engineering Core in Minnesota produces CRISPR/Cas9-mediated knockout and point mutant mice for researchers.

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein ...

Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Intellia's technology platform specializes in Clustered Regularly Interspaced Short ...

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

The same study [13] showed that L1TD1 localizes to high-density RNP condensates and enhances the translation ... bp deletion in the exon 4 of the DNMT1 gene were generated using CRISPR/Cas9 gene ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about genetic safety and efficacy.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

In addition, first-generation CRISPR systems (Cas9 and Cas12a) are too large for efficient in vivo delivery via a single adeno-associated viral (AAV) vector. Now, new preclinical research ...