Editor’s note: Chris Bartlett contributed to this column. From iconic architecture and storied estates, the downtown River District of Fort Myers, Fla., bursts with a vibrant arts and culture scene.

Grab a slice of Key lime pie from Kermit's Key West Key Lime Shoppe a few blocks over, sign up for a ghost tour or catch some live music at the legendary Sloppy Joe's bar. Best of all, you can ...