Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

Using an algorithm they call the Krakencoder, researchers at Weill Cornell Medicine are a step closer to unraveling how the brain's wiring supports the way we think and act. The study, published June ...

Scientists achieved “a milestone” by charting the activity and structure of 200,000 cells in a mouse brain and their 523 million connections. Skip to content Skip to site index ...

PathActMarker is capable of ranking pathways based on the pathway activity matrices, and top-ranked pathways are identified as biomarkers. DOI: 10.1007/s11704-024-40420-y Journal ...

MA-242 exerts potent antitumor activity by modulating metabolic pathways in breast cancer Feb. 26, 2025 Researchers from the University of Houston and Baylor College of Medicine presented preclinical ...

Background: Androgen receptor pathway inhibitors (ARPIs) are standard life-prolonging therapies for patients with metastatic castration-resistant prostate cancer (mCRPC), but patients ultimately ...

Single and multiple doses of ARO-CFB led to near complete inhibition of alternative pathway activity based on Wieslab AP 100% mean reduction achieved by week 4 after a single dose at both 200 mg ...

The spread of antibiotic resistance among bacterial pathogens makes the search for new antimicrobial agents an urgent task. Antimicrobial peptides (AMPs) could be a rich source of new antibiotics (Fox ...

The transcriptional coactivators YAP/TAZ are the critical downstream regulators of the Hippo pathway that regulate gene expression in response to changes in pathway activity, mainly by binding to TEAD ...

This was an experiment for a possible PhD topic. The main idea was to use different Autoencoder for entity resolution / product matching. The core idea was to pretrain an Autoencoder on the positive ...

The Hedgehog (HH) signaling pathway utilizes a core set of components to coordinate diverse cellular processes. In the absence of HH ligand, the 12-pass transmembrane (TM) protein Patched 1 (PTCH1) ...