Aplastic anemia and PNH are both rare disorders, but in some patients they overlap, representing a significant medical challenge. Paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia (AA) are ...

This case report was published in Emerging Infectious Diseases. A 16-year-old girl was diagnosed with PNH and aplastic anemia and was prescribed ravulizumab for severe, chronic hemolysis. She was also ...

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease that develops when your blood cells are formed. It can lead to the abnormal destruction of blood cells, resulting in various symptoms.

One likely cause is an autoimmune response that leads to bone marrow failure. PNH will occur in most people diagnosed with acquired aplastic anemia. This is a serious disease in which bone marrow ...

Several lines of evidence support this mechanism. (1) PNH is closely related to aplastic anemia (AA). (2) PIGA mutant microclones exist in normal people but they do not expand. (3) In PNH patients ...

Immunosuppressive therapy improves pancytopenia in severe aplastic anemia.However, its effects are not long-lasting as evidenced by a modest 2-year EFS rate of just 46%, prompting the need for ...