The quest to resurrect the woolly mammoth on Earth has taken another, well, small step with the creation of the Colossal ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about genetic safety and efficacy.

1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

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CRISPR/Cas9 Modifies Euglena to Create Potential Biofuel Source Sep. 13, 2024 — Through genome editing using CRISPR/Cas9, researchers stably create euglena mutants that can produce wax esters ...

yet the targetable sequence space is limited by the PAM specificity of the Cas9 RNP. This manuscript expands the Cas9 toolbox by defining the PAM specificity and genome editing activity of a large ...

In this study, we established an efficient and simplified protoplast-based genome editing platform for CRISPR-Cas RNP delivery, and then evaluated the efficiency, specificity, and temperature ...

SITE-Seq reportedly detected all previously identified cellular off-targets from preassembled Cas9-gRNA ribonucleoprotein (RNP). Although Digenome-seq sensitivity is equivalent to SITE-Seq, the signal ...

Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had minimal effects on TRAIL sensitivity following CRISPR-Cas9 deletion of caspase-10 in parental cells.