Existing CRISPR/Cas9 gene editing kits currently cost at least $100 per ... has been applied to human genome editing and was recently implemented in the first Food and Drug Administration-approved ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved ...

CRISPR-Cas systems have been exploited for targeted genome editing. CRISPR-Cas13 mediated ... adeno-associated viral gene therapy. SeqCas9, a Cas9 variant from the Streptococcus family, recognizes ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

With the addition of Casgevy, Children’s Hospital Los Angeles now offers two gene therapies for sickle cell, the first being Lyfgenia.