Albumin is the most abundant protein in the bloodstream. It plays several vital roles, including preventing fluid from leaking out of blood vessels and serving various anti-inflammatory functions.

The Saline versus Albumin Fluid Evaluation (SAFE) study was a randomized, double-blind comparison of saline and albumin in a heterogeneous population of intensive care unit patients. The study ...

In the single, randomized, controlled trial that has compared paracentesis plus albumin infusion (10 g/l of ascitic fluid removed) with paracentesis alone, the incidence of circulatory dysfunction ...

The albumin ratio—the ratio of albumin protein in the cerebrospinal fluid compared to levels in the plasma or serum—is considered a measure of blood-brain barrier function, with higher values ...

preliminary evidence [exists] that albumin might be more beneficial than saline for fluid resuscitation in patients with severe sepsis or septic shock... Given the preliminary evidence that ...