Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

Cancer: This loss of motivation doesn't just deepen patients' suffering, it isolates them from family and friends. Because ...

A new study published in npj Metabolic Health and Disease suggests that eating more ultra-processed foods may not only increase the risk of obesity and poor metabolic health, but could also be ...

New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in ...

New research shows that apathy and fatigue in advanced cancer are driven not by physical decline, but by inflammation-sensing neurons that suppress motivation.

High intake of ultra-processed foods is linked to adverse metabolic health and microstructural brain changes in regions that ...

Chronic high-fat diets blunt the brain’s pleasure response to rich foods by impairing NAcLat→VTA signaling in mice. Neurotensin dysfunction underlies this effect, but restoring its signaling revives ...

The developmental progress from daredevil teen to risk-averse senior is more complex than we thought, according to a new study that identified changing relationships between neural structures related ...

Researchers at University of Tsukuba have uncovered the neural mechanisms that regulate sequential male sexual behaviors through studies in male mice. Their findings reveal that acetylcholine neurons ...

Get Instant Summarized Text (Gist) The brain's nucleus accumbens (NAc) plays a crucial role in evaluating stimuli, with D1 and D2 neurons responding to both positive and negative stimuli. Real ...

Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, United States ...