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Once you have Nuitka installed, use nuitka, or python -m nuitka to invoke it. The first thing you’ll want to do with Nuitka is to verify the entire toolchain works, including your C compiler.
Here’s what you can do if you’re stuck with Python ... This doesn’t mean that Python 2 programs won’t compile to Cython anymore, only that Cython code using Python 2 syntax would need ...