Solid Biosciences reports initial clinical data from INSPIRE DUCHENNE trial
Solid Biosciences (SLDB) announced initial data from the Phase 1/2 INSPIRE DUCHENNE trial evaluating SGT-003, a next-generation gene therapy ...
eLife4d
High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation
Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...
PharmiWeb17h
Gilead’s Seladelpar Granted Conditional European Marketing Authorization for the Treatment of Primary Biliary Cholangitis
Gilead Sciences, Inc. (Nasdaq: GILD) today announced that the European Commission (EC) has granted conditional marketing authorization for seladelpar for the treatment of primary biliary cholangitis ...
Nature19d
RNA–protein machines rule
The stunning finding that the ribosome is a ribozyme — that is, that RNA (not protein) catalyzes the peptidyl transferase reaction — has far reaching evolutionary implications. It goes to the ...
C&EN7d
minChemBio: Expanding Chemical Synthesis with Chemo-Enzymatic Pathways Using Minimal Transitions
While a biochemical alternative for step 2 using acetoacetyl-CoA: acetate CoA-transferase reaction is possible, this example highlights the need for careful verification of predicted hybrid pathways ...
gut.bmj11d
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
AH patients had greater aspartate amino transferase/alanine amino transferase ratio and ... severe neutrophil infiltration and ductular reaction were more frequent among AH patients. Transcriptome ...
Solid Biosciences Reports Positive Initial Clinical Data from Next-Generation Duchenne Gene Therapy Candidate SGT-003
Day 90 biopsy data reported from first 3 participants dosed in Phase 1/2 INSPIRE DUCHENNE trial —— Average microdystrophin expression of 110% ...
The Boston Globe6d
Endless phone calls, emails, and political pressure: How intense public reaction shaped Robert F. Kennedy Jr.’s confirmation battle
Kennedy’s confirmation fight featured an array of outside actors, on both sides, working to channel those strong reactions into pleas to senators in hopes of swaying their votes. While outside ...
6abc News11d
Eagles' Super Bowl win over Chiefs sparks widespread reactions
The Philadelphia Eagles are champions again -- in dominant fashion. The Eagles defeated the Kansas City Chiefs 40-22 on Sunday night in Super Bowl LIX. It's the second Super Bowl victory in ...