Background: Methotrexate (MTX) is an anti-folate drug with anti ... due to MTX treatment (3). Thymidylate synthase (TYMS) is involved in thymidine synthesis. MTX decreases TYMS activity by inhibition ...

manchester.ac.uk Background Patients with rheumatoid arthritis (RA) who take methotrexate (MTX) are advised to limit their alcohol intake due to potential combined hepatotoxicity. However, data are ...