Background: Methotrexate (MTX) is an anti-folate drug with anti ... due to MTX treatment (3). Thymidylate synthase (TYMS) is involved in thymidine synthesis. MTX decreases TYMS activity by inhibition ...

TYMS encodes thymidylate synthase, an enzyme critical in the de novo synthesis ... the tumor’s sensitivity to drugs targeting the folate pathway, such as methotrexate. The MTHFR gene is responsible ...

Another antimetabolite, methotrexate, inhibits dihydrofolate reductase, thereby depleting cells of reduced folates, which are required for DNA synthesis. Alkylating agents. Theseinclude melphalan ...

In eukaryotes, PUFAs can be de novo synthesized through two independent biosynthetic pathways: the desaturase/elongase pathway and the PUFA synthase pathway. Among them, PUFAs synthesized through the ...

1 There were remarkable baseline differences: patients developing AAA had more long-standing, severe disease and less often used concomitant medication including lower doses of methotrexate (MTX), ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...