(a) Sequence diagram of the dynein motor domain, showing the functional units: the linker, the ring containing six AAA+ modules, the C sequence and the microtubule-binding domain (MTBD).

To understand the functional role of Gar1 and its cooperativity with the β7_10 loop of Cbf5, we determined a crystal structure of the substrate-bound complex containing the guide RNA, Cbf5 and ...

Combined with the recordings of brain activity, the result is the largest wiring diagram and functional map of the brain to date, containing more than 200,000 cells, four kilometers of axons (the ...