Modifications in proteins after they are synthesized (post-translational) are changes that play a fundamental role in cell ...

The Burkholderia cepacia complex (Bcc) is a group of bacteria including opportunistic human pathogens. Immunocompromised individuals and cystic fibrosis patients are especially vulnerable to serious ...

The findings illustrate a close association of Ras-MAPK pathway activity with SLE pathology. Gene mutations involved in the Ras-MAPK pathway cause a disorder named RASopathy, which shares common ...

Core components of the Hippo pathway were first identified in Drosophila by genetic screens for tissue growth regulators. 24 – 33 Mutations of these genes lead to a common phenotype of tissue ...

Human galectin-3 (hGal-3) is a target protein implicated in various diseases, including fibrosis, and several inhibitors have been identified. In this study, we investigated the quantitative structure ...

Using an algorithm they call the Krakencoder, researchers at Weill Cornell Medicine are a step closer to unraveling how the brain's wiring supports the way we think and act. The study, published June ...

The model structure accounted for: (i) pre-existing phenotype differences in pathway activity among patient tumors and (ii) tumor-specific phenotypic response to therapy. Resistant cancer phenotypes, ...

E75 modulates both Hippo and Notch pathways by binding with their transcriptional effectors—Sd, Yki, NICD, and Su(H) in Drosophila; TEAD, YAP/TAZ, RBPJ, and NICD in mammals—at a transcriptional and ...

ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, ... abnormal activation of the renin–angiotensin system activity, chronic ...

The “ggplot2” package was used to draw boxplots to compare the differences in immune cells infiltration and immune pathways activity between the SAP and control groups. A subset of MAPK14 expression ...