A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.

P-cadherin is embedded in the cell membrane as a dimer ... P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. “Our results establish an outside ...

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell.

The scientists found that the Y1816C variant twisted the structure of the third 3Fn domain ... a process in which lysosomes fuse with the plasma membrane to dump their contents outside of the cell ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.

Thus, the lamellar ER is a complex structure consisting of both ER membrane ... which subsequently expand and close to form double-membrane autophagosomes. The autophagosome further fuses with the ...