LA Galaxy are all set to host San Diego FC in the MLS 2025 Western Conference fixture. Galaxy finished second in the last season.

San Diego FC is playing its first-ever MLS game this weekend in a primetime matchup that adds a new layer to the city's "Beat L.A." mantra.Why it matters: The historic game against LA Galaxy officially kicks off SDFC's 2025 inaugural season as the newest franchise in a league that's rapidly grown to 30 teams in 30 years.

Here’s a rundown of what the league is, who plays in it, how to watch it and more as SDFC prepares to take on the LA Galaxy

The Galaxy may be the defending champs, but they'll look considerably different than when they slayed the NY Red Bulls 2-1 in the MLS Cup final last December. Striker Dejan Joveljic is in Kansas City, Riqui Puig is out with a long-term injury, and Joseph Paintsil is still working back from a shorter-term issue.

San Diego FC will kick off the 30th MLS season with their first game on Sunday in Carson against LA Galaxy, followed by their first home game March 1 against St. Louis City SC at Snapdragon Stadium.

San Diego FC recognizes the nonprofit San Diego Independent Supporters Union, which is made up of seven groups: 18th Battalion, Barra 18, Chavos Frontera Ultras, Daygo Boys, The Locals, Riptides and USG 18. The supporters groups work together on community efforts, gameday atmosphere and events.

Lozano is the star on Major League Soccer's 30th team, which kicks off its first season Sunday with a match on the road against the defending league champion LA Galaxy. Lozano said he's looking forward to seeing where San Diego is at to start the season,

San Diego FC is set to make its highly-anticipated regular season debut on Sunday with an away match against the Los Angeles Galaxy.

The betting odds and our top pick for when LA Galaxy hosts San Diego FC in both team's 2025 MLS regular season opener.