The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...
No safety concerns emerged in part one of the phase 1 trial assessing CS014, a histone deacetylase inhibitor that has ...
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish ...
The Wistar Institute's Filippo Veglia, Ph.D., and lab has discovered a previously unknown mechanism for how aggressive brain ...
How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell development in chickens, the investigators started with whole chromatin from ...
In a preprint uploaded to bioRxiv this January that has yet to undergo peer review, the team describes hundreds of potential histone proteins in bacteria, including one that they predict interacts ...
These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...
In addition, the team proposed that non-histone lactylation levels accumulate progressively from 1 week to 6 months (6 m), whereas histone lactylation levels decrease rapidly from 1 to 6 weeks ...
N. Hertzog et al., Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8, Nature Communications, 9 January 2025, DOI: 10.1038/s41467-025-55835-9 ...
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