The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive ...

The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

No safety concerns emerged in part one of the phase 1 trial assessing CS014, a histone deacetylase inhibitor that has ...

New research has uncovered a mechanism by which brain cancer cells reprogram immune cells from fighting cancer to enabling ...

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish ...

In a preprint uploaded to bioRxiv this January that has yet to undergo peer review, the team describes hundreds of potential histone proteins in bacteria, including one that they predict interacts ...

How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell development in chickens, the investigators started with whole chromatin from ...

Scientists have discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth.

Targeted protein degradation (TPD) is an alternative to conventional protein inhibition that is gaining attention due to advantages such as ensuring complete elimination of the target protein, reduced ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

In addition, the team proposed that non-histone lactylation levels accumulate progressively from 1 week to 6 months (6 m), whereas histone lactylation levels decrease rapidly from 1 to 6 weeks ...