Biological mechanisms for nuclease-based gene editing technologies ... Both ZFN and TALEN systems locate similar FokI endonucleases (the dark blue combined sphere) by DNA-binding domains on the left ...

Similar to ZFNs, TALENs are programmable DNA-binding nucleases with the catalytic domain of the FokI endonuclease fused to transcription ... Domains HNH and RuvC are nuclease domains that cut ...

GMP GENIUS ™ Nuclease is a tag-free recombinant form of Serratia marcescens extracellular endonuclease, produced in Escherichia coli through a proprietary process at ACROBiosystems. It functions ...

GMP Salt Active GENIUS ™ Nuclease is developed using ACROBiosystems' unique enzyme AI evolution platform, based on wild-type Serratia marcescens endonuclease. It maintains high specific activity ...

Now, new preclinical research presents the discovery and engineering of NanoCas—an ultracompact CRISPR nuclease capable of extending CRISPR’s reach in vivo beyond liver targets. NanoCas is the ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

Danielle is an Assistant Editor at The Scientist. She has a background in neuroscience and molecular psychiatry. She has previously written for BioTechniques News, The Scientist, and Drug Discovery ...