A research team have recently published their article, "Rationally designed pooled CRISPRi-seq uncovers an inhibitor of bacterial peptidyl-tRNA hydrolase" in Cell Reports. In this study ...

The performance comparison shows that CRISPRlnc is far superior to existing methods for lncRNA-specific sgRNA design in both CRISPRko and CRISPRi mechanisms," said Liu Changning of XTBG.

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...

The other two either activate (CRISPRa) or inhibit (CRISPRi) the expression of a gene without altering the DNA. CRISPR screening is an application of this technology, and we can do the screens in ...