Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9)-mediated technology ... without creating a double-strand break (DSB) in the DNA, reducing unwanted ...

The first subject has now been given a dose of VERVE-101, in what is thought to be the first test in humans of an experimental CRISPR/Cas9 genome ... therapies generate a DSB at a precise location ...

DSB, double-strand breaks; NHEJ ... unrelated healthy individuals need to be recruited to generate hiPSC-CMs under the same conditions. CRISPR/Cas9-edited hiPSCs can then insert the same mutations ...

Including gene editing components, the type of DNA damage, double-strand break repair mechanisms, donor DNA, and mutation types of ZFN, TALEN, CRISPR-Cas9, and CRISPR-Cas12 ... NHEJ and HDR are two ...

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and ...

Scientists are exploring gene editing as a way to correct trisomy at the cellular level. Using CRISPR-Cas9, researchers ...

A new review in Engineering reveals that CRISPR technologies are revolutionizing regenerative medicine. Scientists from ...

CRISPR technology, driven by Cas9, redefines gene editing, facilitating targeted DNA modifications that advance genetic ...

When Vijay Sankaran was an MD-PhD student at Harvard Medical School in the mid-2000s, one of his first clinical encounters ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about genetic safety and efficacy.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro ...