The 49ers expect tight end George Kittle to practice Wednesday and cornerback Charvarius Ward has returned to the team and will be evaluated in hopes of returning in Week 12 to face the Buffalo Bills.

The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to ...

The AFC had a major shake-up after the thrilling Week 11 slate, even if not much changed in the standings. The Kansas City ...

The injury-prone San Francisco 49ers are monitoring yet another health issue, this one involving quarterback Brock Purdy's ...

Meanwhile, Harbaugh is in Los Angeles, coaching the Chargers to a 7-3 record, with quarterback Justin Herbert looking like a ...

Star pass-catcher Jayden Reed and the Green Bay Packers play the San Francisco 49ers on Sunday at 4:25 p.m. ET, at Lambeau ...

One of the best pass-catchers in the NFL will be on show when Trey McBride and the Arizona Cardinals visit the Seattle ...

After falling to 5-5 with a disappointing 20-17 loss to the Seattle Seahawks on Sunday, the San Francisco 49ers received even ...

What are the lines we're looking at before movement later in the week? Here are some early picks for Week 12 of the NFL and ...

The breakdowns in the San Francisco 49ers' crushing loss to the Seattle Seahawks can be found in their PFF grades.

Technically, you could blame the defense for the 49ers' 20-17 loss to the Seahawks on Sunday because the defense couldn't close out the game. It gave up an 80-y ...

With a devastating loss in Week 11, the 49ers’ two-game win streak came to an end as they fell to 5-5 and to last place in ...