UPMC researchers have been following the question of their role in scleroderma-related pathology for more than 30 years. In 1990, Thomas Medsger Jr., MD, and a colleague published a study of 371 ...

Scleroderma is an autoimmune, rheumatic, and chronic disease that affects the body by hardening connective tissue, according to the Johns Hopkins Scleroderma Center. For the almost 500,000 people in ...

systemic sclerosis—also known as scleroderma—can affect the skin as well as other organs. Most research has focused on the pathology and starting point of fibrosis, but researchers at the ...

Better histology outcomes in the skin biopsies correspond with greater improvement in the modified Rodnan Skin Score (mRSS), a standard measurement of skin improvement in systemic sclerosis and ...

Scleroderma is classified as a rare, autoimmune, collagen-vascular disease of unknown etiology that can be difficult to diagnose and treat. Its onset can be insidious or rapid; the symptoms range ...