Figure 3: Stop codon configuration in the eukaryotic decoding centre. Purines would be disfavoured at the +1 position by steric hindrance with eRF1, while cytidine would be incompatible with the ...

This effect suggests that streptomycin stabilizes the ribosome in a conformation that sustains moderate GTPase activation independent of whether there is cognate or near-cognate codon recognition ...

“A model explains these codon-context effects by suggesting that codon recognition by elongation factor-bound aminoacyl-tRNA is initiated by hydrogen bond interactions between the first two ...

allowing for more flexibility in codon recognition. Wobble base pairing enables a single tRNA molecule to recognize multiple codons for the same amino acid, reducing the number of tRNA molecules ...

The key structural features of tRNA include: The specificity of tRNA-amino acid interactions and the accuracy of codon-anticodon recognition ensure the faithful translation of the genetic code into ...