Patients do not typically transition to an upper motor neuron bladder or bowels Bladder and bowel anal-rectal sphincter remains flaccid, becomes highly complaint and is characterized by underactivity ...

the primary characteristic of this disease is the selective degeneration of upper and lower motor neurons, initiating in mid-adult life and almost invariably progressing to paralysis and death ...

Otuoma died after a long battle with Motor Neurone Disease ... and can affect the upper and/or lower motor neurons. It causes rapid loss of muscle control and eventual paralysis.

Motor neurone disease (MND ... ALS affects both the upper motor neurones that travel from the brain to the spinal cord and the lower motor neurones, which branch out to the various muscle groups ...