Man’s deadliest foes as the Sinister Six: Doctor Octopus, the Vulture, Electro, Mysterio, Sandman, and Kraven the Hunter.

But before he gets a chance, Spider-Man has a run-in with Mysterio. When the Sinister Six escape from prison with plans to take down Spider-Man, they nearly succeed. But Peter wakes up with no memory ...

Man's oldest foes and his villainous successor are embarking on a new kind of partnership, and the sparks are flying.