President Trump offered his most critical comments at Russian President Vladimir Putin for comments he made about the leader of Ukraine.

US president Donald Trump is “very angry” and “p***** off” with Vladimir Putin for his suggestion Volodymyr Zelensky should be replaced by a UN-mandated government, according to NBC News.Mr Trump told the US network he was furious with the Russian leader over his suggestion a temporary administration should be installed to replace Mr Zelensky.

Ukraine's General Staff said the strikes were a "deliberate, targeted striking" of the hospital and that it appeared soldiers being treated there were injured.

Russian drones struck several targets in Kharkiv, Ukraine's second largest city, late on Saturday, killing one person and injuring at least nine, local officials said.

Ukraine's State Emergency Service reported a massive Russian strike late on Sunday and Monday morning in Ukraine's second-largest city of Kharkiv.

Ukrainian forces have responded to Russian efforts to expel them from one part of Russian territory by launching a large number of attacks on another border area, using drones, artillery and troops.

Ukraine expected a strong response from Western countries to the nearly daily Russian drone attacks on its territory.

Another 21 people are injured, as a restaurant and several buildings are set ablaze in the city, local officials say.

Regional governor Oleh Syniehubov said a 67-year-old man and a 70-year-old woman were killed in the attack on Ukraine’s second-largest city. Ukraine’s General Staff denounced the “deliberate, targeted shelling” of the military hospital.