The F and G proteins are the only viral components that induce neutralizing antibodies and are the primary targets of the humoral response. RSV is a major seasonal viral respiratory pathogen in ...

Zhu and his research team first analyzed the F proteins used in the development of four existing RSV vaccines—the commercially available Arexvy, mResvia and Abrysvo, and an experimental vaccine ...

The trimeric pre-fusion glycoprotein F is essential for accurately assessing the immunogenicity of RSV vaccines. We strictly adhere to ... whether it comes through recombinant proteins, antibodies, ...

First, they must enter the host cells, which RSV does using its fusion (F) protein. Vaccines induce antibodies that bind to pathogens. Neutralizing antibodies bind to crucial sites, such as part ...

The two vaccines induce the immune system to target a critical protein on the surface of RSV, the F protein, in its pre-infection form, known as pre-fusion F. High levels of antibodies against pre ...

RSV F is a class 1 fusion protein and undergoes a dramatic refolding to mediate ... and is particularly recognized for his research on respiratory viruses, structure-based vaccine design, and ...

BLB201 encodes the RSV F protein and uses a proprietary PIV5 vector, which is not known to cause human disease. PIV5 has been commonly administered to dogs as part of combination distemper/kennel ...

Background RSV is a ubiquitous pathogen causing severe disease in children ... Forty-eight participants were randomly assigned to either the low-dose (140 µg F-protein-FP/2 mg BLPs) or high-dose group ...

Here, we describe the epidemiology of RSV, the RSV virion structure ... the small hydrophobic protein, the glyco (G) attachment protein and the fusion (F) protein. The F and G proteins are ...