Some libraries are easier to learn and use than others ... library that is easy to use and customize. Tkinter is a standard GUI library for Python, and it is the most popular Python GUI framework.

The beauty of pyGTK and Glade is they have opened up cross-platform, professional-quality GUI development ... than runtime speed. This combination leads you to choose from the following alternatives ...

I’ve used WxWidgets, too, and other than how many “extra” things you want, these are all easy enough to use. However, I had written the code in Python ... in GUI programs. Some tkinter ...