Nowell is best known for co-discovering the Philadelphia chromosome while at the University of Pennsylvania with his colleague, David Hungerford of the Fox Chase Cancer Center. While investigating ...

CML is a blood cancer linked to a genetic mutation known as the Philadelphia chromosome. This mutation drives uncontrolled ...

This discovery meant that specificity might ... there was also cytogenetic remission, meaning that the Philadelphia chromosome was no longer found in their blood cells. As Druker noted, "That ...

An example of a balanced structural change is the Philadelphia chromosome translocation previously described. In that case, although genetic information was rearranged into an abnormal gene ...