Damaged muscles in ALS patients release proteins previously linked only to brain disease In a nutshell Researchers discovered ...

cause a rare form of familial ALS. Multiple lines of evidence suggest that TDP-43 pathology may result from both gain and loss of function of this protein. We have found that overexpression of human ...

One such disease is ALS, a degenerative disease of the motor ... "It is still possible to detect AD pathology, but not as precisely as one would like or in the way that is often suggested.

The major focus of our studies has been the identification of the cellular and molecular mechanisms by which specific proteins central to these diseases (e.g., the beta amyloid peptide in AD and ...

In ALS, TDP-43 pathology is understood to spread via extracellular vesicles, including neuronal exosomes, which are secreted by sick neurons and can be taken up by healthy ones. TDP-43 pathology ...

Stress granules (SGs) are transient organelles that form when cells experience stress, serving as critical hubs for RNA metabolism and cellular survival.