Roche has entered into an agreement with Evotec to fund the Phase II clinical development of a selective N-methyl-D-aspartate (NMDA) receptor antagonist, EVT 101, for patients with treatment ...

It is the first and only oral NMDA receptor antagonist to be approved for this use, and the first oral therapy with a new mechanism of action in around 60 years, said Axsome.

NMDA receptors are heteromeric tetramers composed of two obligatory GluN1 and two alternative subunits, either GluN2 (N2A to N2D) or GluN3 (N3A and N3B). Over the past decade, molecular ...

"Most NMDA receptors are found in synapses, where they enhance neuronal connections. However, those located outside the synapse are more associated with processes of toxicity and cell death, which ...

Samantha Schwarz, a doctoral candidate in the neuroscience program, won the second place prize of $1,500 in UB’s ninth annual Three Minute Thesis (3MT) competition.

General anesthetics work by altering the activity of specific neurons in the brain. One main class of these drugs, which includes propofol and the ether-derivative sevoflurane, work primarily by ...